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Intracerebral Hemorrhage After Intravenous t-PA Therapy for Ischemic Stroke The NINDS t-PA Stroke Study Group, Stroke 28:2109-21181997., , 1997 See this aricle in Pubmed Article Abstract Despite a higher rate of intracerebral hemorrhage,patients with severe strokes or edema or mass effect on the baseline CT are reasonable candidates for t-PA,if it is administered within 3 hours of onset.

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